ENERGYAND DEFENSE

Descrizione

The aim of this book is to introduce the bases of the biochemical and medical implications of Coenzyme Q. The discovery of this molecule came about within an intensive program of research, developed by Prof. D.E. Green, at the University of Wisconsin, to find out how mitochondria work. This happened in 1957; it soon became evident that Coenzyme Q was essential to mitochondrial ATP formation. Several years later Prof. P. Mitchell was awarded the Nobel prize, for this studies centered on the vital role of Coenzyme Q it is necessary to illustrate the cellular context in which Coenzyme Q is located. Therefore the mechanisms by which mitochondria harness the energy originally enclosed in the biological fuels will be outlined in the initial chapters of this book. The insight of Prof. Karl Folkers, who since those early years reisolated Coenzyme Q10, the human Coenzyme Q, from hyman heart, and elucidated its structure, led him to foresee the clinical importance of Q10. At the same time Prof. Yuichi Yuamamura, a pioneer of CoQ10 research in cardiology, developed the first clinical trial of CoQ10 in patients with cardiovascular disease. Those intuitions opened a new, variegated, biomedical research field, whose acquisitions expanded together with the basic biochemistry of Coenzyme Q